Silicotic lung of rats were prepared by inclusion of free silica particles through the
trachea and after 2 months, unclassified mycobacteria were inoculated intravenously, and
obeservations were carried out on the weight of whole body and various organs (lung,
liver, spleen and kidney), the isolation rate of the organisms from each organs and the
pathological change of the lungs.
The results obtained were as follows :
1) Although the body weight was reduced, the weight of the lungs, liver and spleen
were increared.
2) The isolation rates of mycobacteria from each organs showed higher than those of
non-silicotic rats.
3) The lung showed some pathological change.
4) Photochromogen was highest change among them and decreased in order of
nonphotochromogen, tubercle bacilli, rapid grower and scotochromogen.
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